Kainate-type Glutamate Receptors Modulating Network Activity in Developing Hippocampus
نویسندگان
چکیده
viii 1 Review of the literature 1 1.2 Development of hippocampal network 2 1.3 Properties of kainate receptors 5 1.3.1 Structure 5 1.3.3 Pharmacology 10 1.3.2 Signaling 8 1.4 Kainate receptors in immature hippocampus 12 1.4.1 Expression 12 1.4.2 Functions 14 1.4.3 Role in network activity 18 1.5 Ethanol and the developing hippocampus 21 2 Aims 24 3 Materials and methods 25 3.1 Preparation of acute hippocampal slices 25 3.2 Electrophysiological recordings 25 3.3 Data analysis 29 4 Results 30 4.1 Activation of high-affinity kainate receptors promotes network burst generation via enhancing spontaneous spiking of immature CA3 pyramidal neurons (I) 30 4.2 Subunit GluK1-containing kainate receptors regulate network activity via metabotropically controlling afterhyperpolarization in immature interneurons (II) 34 4.3 Block of GluK1-containing kainate receptors suppresses network effect of ethanol in a developmental manner (III) 37 5 Discussion 39 6 Conclusions 46 Acknowledgements 47 References 48
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